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Polo-like kinase 1 (PLK1) is a key regulator enzyme of cell cycle progression, which belongs to a kinase family named Polo-like kinases [1, 2].This family is characterized by a C-terminal domain termed Polo-box domain (PBD), which represents a regulatory domain for the function of the N-terminal Ser/Thr kinase domain [].PLK1 is activated during mitosis [].
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Without Sec62, the translocation pore of Sec61 remains closed by the plug domain, rendering the channel inactive. We further show that the lateral gate of Sec61 must first be partially opened by interactions between Sec61 and Sec63 in cytosolic and luminal domains, a simultaneous disruption of which completely closes the channel.
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The POLO-Box domain is exclusively found in the family of Polo-like kinases that regulate mitotic entry, spindle assembly, centrosome maturation, chromosome segregation, cytokinesis and cell cycle arrest. The approximately 200 amino acid POLO-Box domain consists of two highly conserved Polo Box motifs of ~70-80 amino acids each, and is.
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About the Home. Crossings at Silver Lake offers the only new homes walkable to Middletown's Main Street, adjacent to the new library, YMCA & Silver Lake Park.Outdoor living & 2-car garage included. The Serenade offers an updated take on townhome living. Enter through the foyer on the lower level, where a quiet study makes work-from-home easy and an included recreation room is ideal for game.
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The domain name (second-level domain) is a sub-domain of the TLD, the third-level domain is a sub-domain of the second-level domain, and so on. For country-code second-level domains such as ".co" in example.co.uk, the actual domain name ("example") becomes the third-level domain.
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Domain names and IP numbers are the framework upon which the entire world wide web is built. IP numbers are assigned to networking organisations with a record maintained by governing bodies for each IP number and the organisation to which it has been assigned. A whois IP lookup allows you track the above mentioned details for a domain.
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The polo-box domain: a molecular integrator of mitotic kinase cascades and polo-like kinase function. Cell Cycle. 2004; 3:128-31. doi: 10.4161/cc.3.2.660. [Google Scholar] Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with.
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Introduction. Polo-like kinase 1 (PLK1), a member of the Polo-like kinase (PLK) family, is an enzyme mainly involved in cell cycle progression , .PLKs consist of an N-terminal Ser/Thr kinase domain and a C-terminal regulatory Polo-box domain (PBD), which is characteristic for this family of kinases .The PBD is crucial for the ligand binding and subcellular localization of kinases .
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Polo-like kinases (Plks) are the key regulators of cell cycle progression, the members of which share a kinase domain and a polo-box domain (PBD) that serves as a protein-binding module. While Plk1 is a promising target for antitumor therapy, Plk2 is regarded as a tumor suppressor even though the two Plks commonly recognize the S-pS/T-P motif.